Shehata-Dieler W E, Dieler R, Teichert K, Moser L M
Bayerische Julius-Maximilians-Universität, Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke.
Laryngorhinootologie. 1999 Jun;78(6):345-50. doi: 10.1055/s-2007-996884.
Distortion product otoacoustic emissions (DPOAEs) are evoked by simultaneously stimulating the cochlea with two tones. The DPOAE with the highest amplitude (at the frequency 2f1-f2) is usually used for routine audiological evaluation. Any interpretation of DPOAEs in a clinical setting must consider their intra- and intersubject variability.
DPOAE measurements were performed in 36 normally hearing adults in three weekly test sessions. Each ear was tested twice per session, and the results were statistically analyzed.
All test candidates had measurable DPOAEs. Statistically significant differences in absolute DPOAE amplitudes were neither found between two measurements at the same day, nor at weekly intervals, nor between right and left ear of the same candidate. Absolute DPOAE amplitudes in women were significantly higher in the 2-6 kHz range whereas they presented with significantly lower amplitudes below 2 kHz when compared to men.
The present results indicate that monitoring of the inner ear status can be reliably performed using DPOAE measurements. Change in DPOAE amplitudes effectively indicate changes in the cochlear function with high sensitivity. Compared to TEOAE measurements, DPOAEs offer a higher frequency resolution in a broader frequency band and thus more detailed information about the cochlear condition.
畸变产物耳声发射（DPOAE）是通过同时用两个纯音刺激耳蜗而诱发的。通常将振幅最高的DPOAE（频率为2f1 - f2）用于常规听力学评估。在临床环境中对DPOAE的任何解读都必须考虑其个体内和个体间的变异性。
对36名听力正常的成年人进行了为期三周的DPOAE测量，每周进行一次测试。每次测试时每只耳朵测试两次，并对结果进行统计学分析。
所有受试对象均能检测到DPOAE。在同一天的两次测量之间、每周测量之间以及同一受试对象的左右耳之间，均未发现DPOAE绝对振幅存在统计学上的显著差异。与男性相比，女性在2 - 6 kHz范围内的DPOAE绝对振幅显著更高，而在2 kHz以下则显著更低。
目前的结果表明，使用DPOAE测量可以可靠地监测内耳状态。DPOAE振幅的变化能够以高灵敏度有效指示耳蜗功能的变化。与瞬态诱发耳声发射（TEOAE）测量相比，DPOAE在更宽的频带内具有更高的频率分辨率，从而能够提供关于耳蜗状况更详细的信息。
