Matolcsy A
Department of Pathology, University Medical School of Pécs, Hungary.
Leuk Lymphoma. 1999 Jul;34(3-4):251-9. doi: 10.3109/10428199909050950.
In the natural history of low-grade non-Hodgkin's lymphomas (NHL) a prolonged indolent phase of the disease may be followed by clinical progression toward intermediate and high-grade disease. The abrupt appearance of diffuse large cell lymphoma (DLL) in patients with low-grade NHL is usually associated with an accelerated clinical course and shorter time of survival. The histologic transformation has been described for chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL), follicular lymphoma (FL), mantle cell lymphoma (MCL) and lymphoma of mucosa-associated lymphoid tissue (MALT). Although the histological transformation of low-grade lymphomas are relatively frequent, the clonal relationship between the two neoplasms and pathogenetic mechanisms underlying the progression of the disease are widely debated. In this review, we will focus on the possible relationship between the low-grade and the transformed high-grade NHLs and genetic lesions that may be associated with the histologic transformation and clinical progression of the disease.
在低度非霍奇金淋巴瘤（NHL）的自然病程中，疾病的惰性期延长后可能会临床进展为中度和高度疾病。低度NHL患者中弥漫性大细胞淋巴瘤（DLL）的突然出现通常与临床病程加速和生存期缩短有关。慢性淋巴细胞白血病或小淋巴细胞淋巴瘤（CLL/SLL）、滤泡性淋巴瘤（FL）、套细胞淋巴瘤（MCL）以及黏膜相关淋巴组织淋巴瘤（MALT）均有组织学转化的报道。尽管低度淋巴瘤的组织学转化相对常见，但两种肿瘤之间的克隆关系以及疾病进展的发病机制仍存在广泛争议。在本综述中，我们将重点关注低度和转化后的高度NHL之间的可能关系以及可能与疾病的组织学转化和临床进展相关的基因损伤。
