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[使用葡甲胺锑酸盐治疗利什曼病期间发生的尖端扭转型室速]

[Torsades de pointes during treatment of leishmaniasis with meglumine antimoniate].

作者信息

Castelló Viguer M T, Echánove Errazti I, Ridocci Soriano F, Esteban Esteban E, Atienza Fernández F, Cuesta Estellés G

机构信息

Servicio de Cardiología, Hospital General Universitario, Valencia.

出版信息

Rev Esp Cardiol. 1999 Jul;52(7):533-5.

Abstract

Antimonial agents are the main drug to treat all forms of leishmaniasis. Meglumine antimoniate is the drug available in Spain and it is usually well tolerated. Nevertheless, this drug frequently alters ventricular repolarization, but few cases of sudden death, presumably related to ventricular arrhythmias, have been reported. We present a case of torsade de pointes during treatment with meglumine antimoniate coexisting with a severe hypokalemia probably due to an acute transitory tubulopathy.

摘要

锑剂是治疗所有类型利什曼病的主要药物。葡甲胺锑酸盐是西班牙可获得的药物,通常耐受性良好。然而,这种药物经常会改变心室复极,但据报道很少有猝死病例,推测与室性心律失常有关。我们报告一例在用葡甲胺锑酸盐治疗期间发生尖端扭转型室速的病例,同时存在严重低钾血症,可能是由于急性短暂性肾小管病所致。

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