Shiota T, Jones M, Aida S, Chikada M, Tsujino H, El-Kadi T, Sahn D J
Cleveland Clinic Foundation, Ohio, USA.
J Am Coll Cardiol. 1999 Aug;34(2):587-93. doi: 10.1016/s0735-1097(99)00210-7.
The aim of the present study was to quantitate shunt flow volumes through atrial septal defects (ASDs) in a chronic animal model with surgically created ASDs using a new semiautomated color Doppler flow calculation method (ACM).
Because pulsed Doppler is cumbersome and often inappropriate for color flow computation, new methods such as ACM are of interest.
In this study, 13 to 25 weeks after ASDs were surgically created in eight sheep, a total of 24 hemodynamic states were studied at a separate open chest experimental session. Electromagnetic (EM) flow probes and meters were used to provide reference flow volumes as the pulmonary and aortic flow volumes (Qp and Qs) and shunt flow volumes (Qp minus Qs). Epicardial echocardiographic studies were performed to image the left and right ventricular outflow tract (LVOT and RVOT) forward flow signals. The ACM method digitally integrated spatial and temporal color flow velocity data to provide stroke volumes. RESULTS Left ventricular outflow tract and RVOT flow volumes obtained by the ACM method agreed well with those obtained by the EM method (r = 0.96, mean difference = 0.78 +/- 1.7 ml for LVOT and r = 0.97, mean difference = -0.35 +/- 3.6 ml for RVOT). As a result, shunt flow volumes and Qp/Qs by the ACM method agreed well with those obtained by the EM method (r = 0.96, mean difference = -1.1 +/- 3.6 ml/beat for shunt volumes and r = 0.95, mean difference = -0.11 +/- 0.22 for Qp/Qs).
This animal study, using strictly quantified shunt flow volumes, demonstrated that the ACM method can provide Qp/Qs and shunt measurements semiautomatically and noninvasively.
本研究的目的是使用一种新的半自动彩色多普勒血流计算方法（ACM），对通过手术制造房间隔缺损（ASD）的慢性动物模型中的ASD分流血流量进行定量。
由于脉冲多普勒操作繁琐且通常不适用于彩色血流计算，因此诸如ACM之类的新方法备受关注。
在本研究中，在八只绵羊手术制造ASD后的13至25周，在单独的开胸实验阶段共研究了24种血流动力学状态。使用电磁（EM）流量探头和测量仪提供作为肺血流量和主动脉血流量（Qp和Qs）以及分流血流量（Qp减去Qs）的参考流量。进行心外膜超声心动图研究以成像左心室和右心室流出道（LVOT和RVOT）的正向血流信号。ACM方法对空间和时间彩色血流速度数据进行数字积分以提供每搏输出量。结果通过ACM方法获得的左心室流出道和RVOT血流量与通过EM方法获得的血流量高度吻合（LVOT：r = 0.96，平均差异= 0.78±1.7 ml；RVOT：r = 0.97，平均差异= -0.35±3.6 ml）。因此，通过ACM方法获得的分流血流量和Qp/Qs与通过EM方法获得的结果高度吻合（分流血流量：r = 0.96，平均差异= -1.1±3.6 ml/搏；Qp/Qs：r = 0.95，平均差异= -0.11±0.22）。
这项使用严格定量分流血流量的动物研究表明，ACM方法可以半自动且无创地提供Qp/Qs和分流测量值。
