Shiota T, Jones M, Aida S, Tsujino H, Yamada I, Delabays A, Pandian N G, Sahn D J
Oregon Health Sciences University, Portland, Oregon, USA.
J Am Coll Cardiol. 1997 Sep;30(3):834-42. doi: 10.1016/s0735-1097(97)00210-6.
The aim of the present study was to quantitate aortic regurgitant volume and regurgitant fraction in a chronic animal model with surgically created aortic regurgitation using a new semiautomated color Doppler flow calculation method.
The conventional noninvasive methods for evaluating the severity of aortic regurgitation have not been accepted widely nor compared with truly quantitative reference standards.
Eight to 20 weeks after aortic regurgitation was surgically induced in six sheep, a total of 22 hemodynamic states were studied. Electromagnetic flow probes and meters provided reference flow data. Epicardial color Doppler echocardiographic studies were performed to image left ventricular outflow tract forward and aortic regurgitant blood flows. The new method digitally integrated spatial and temporal color flow velocity data for left ventricular outflow tract forward flow and ascending aortic regurgitant flow. The pulsed Doppler method using the velocity-time integral was also used to obtain regurgitant volumes and regurgitant fractions.
Regurgitant volumes and regurgitant fractions by the new method agreed well with those obtained electromagnetically, whereas the pulsed Doppler method overestimated these reference data (mean [+/-SD] difference 0.23 +/- 2.9 ml vs. 11 +/- 5.8 ml, p < 0.0001 for regurgitant volume; mean difference 1.2 +/- 7.6% vs. 19 +/- 13%, p < 0.0001 for regurgitant fraction).
This animal study, using strictly quantified aortic regurgitant volumes, demonstrated that the digital color Doppler method provides accurate aortic regurgitant volumes and regurgitant fractions without cumbersome measurements.
本研究旨在利用一种新的半自动彩色多普勒血流计算方法，对手术造成主动脉反流的慢性动物模型中的主动脉反流容积和反流分数进行定量分析。
评估主动脉反流严重程度的传统非侵入性方法尚未被广泛接受，也未与真正的定量参考标准进行比较。
在6只绵羊手术诱发主动脉反流8至20周后，共研究了22种血流动力学状态。电磁血流探头和测量仪提供参考血流数据。进行心外膜彩色多普勒超声心动图研究，以成像左心室流出道正向血流和主动脉反流血流。新方法对左心室流出道正向血流和升主动脉反流血流的空间和时间彩色血流速度数据进行数字整合。还使用基于速度时间积分的脉冲多普勒方法来获取反流容积和反流分数。
新方法得到的反流容积和反流分数与电磁法得到的结果高度一致，而脉冲多普勒方法高估了这些参考数据（反流容积的平均[±标准差]差值为0.23±2.9 ml对11±5.8 ml，p<0.0001；反流分数的平均差值为1.2±7.6%对19±13%，p<0.0001）。
这项使用严格量化的主动脉反流容积的动物研究表明，数字彩色多普勒方法可提供准确的主动脉反流容积和反流分数，且无需繁琐的测量。
