Ongrádi J, Miheller P, Csiszár A, Menezes J, Maródi C L, Sréter L, Horváth A
Országos Bör- és Nemikórtani Intézet, Budapest.
Orv Hetil. 1999 Jun 27;140(26):1457-9.
DNA sequences, antigens and elevated antibodies to HHV-6, and DNA sequences of HHV-7 in patients with Hodgkin's disease and non-Hodgkin's lymphoma have been detected. It is not known whether HHV-6 variants A and B, and HHV-7 contribute to the malignization by different ways, there is any interaction between these viruses, and their primary or recurrent infections occur during the disease progression. Total and high avidity IgG, IgM to HHV-6A, HHV-6B and HHV-7 were quantitated simultaneously in the sera of 12 patients with lymphomas and 12 control persons by indirect immunofluorescent assay and ELISA. It was established that, primary infection by HHV-6B in Hodgkin's disease, its primary or recurrent infections in non-Hodgkin's lymphoma; primary or recurrent infection by HHV-6A in Hodgkin's disease, its recurrent infection in non-Hodgkin's lymphoma; recurrent infection by HHV-7 in Hodgkin's disease may contribute to the deterioration of clinical conditions. Probably, HHV-7 exerts its effects through activating HHV-6B. The simultaneous effects of HHV-7 and HHV-6A, and that of HHV-6B and HHV-6A seem to be independent. Our results supports the recent opinion that, the effect of these herpesviruses on the tumorous cells is exerted indirectly by altered mediators of the immune system.
在霍奇金病和非霍奇金淋巴瘤患者中已检测到HHV-6的DNA序列、抗原和升高的抗体，以及HHV-7的DNA序列。尚不清楚HHV-6 A和B亚型以及HHV-7是否通过不同方式促成恶性转化，这些病毒之间是否存在相互作用，以及它们的原发性或复发性感染是否在疾病进展过程中发生。通过间接免疫荧光测定法和酶联免疫吸附测定法同时对12例淋巴瘤患者和12名对照者血清中的HHV-6A、HHV-6B和HHV-7的总IgG、IgM以及高亲和力IgG、IgM进行定量。结果表明，HHV-6B在霍奇金病中的原发性感染、在非霍奇金淋巴瘤中的原发性或复发性感染；HHV-6A在霍奇金病中的原发性或复发性感染、在非霍奇金淋巴瘤中的复发性感染；HHV-7在霍奇金病中的复发性感染可能导致临床病情恶化。可能，HHV-7通过激活HHV-6B发挥作用。HHV-7与HHV-6A的协同作用以及HHV-6B与HHV-6A的协同作用似乎是独立的。我们的结果支持了最近的观点，即这些疱疹病毒对肿瘤细胞的作用是通过免疫系统改变的介质间接发挥的。
