Maeda N, Yoshida T, Sonoda T, Kanayama Y, Cho S, Nishizaki S
Department of Urology, Ashiya Municipal Hospital.
Hinyokika Kiyo. 1999 Jun;45(6):447-50.
A 35-year-old male had advanced nonseminomatous germ cell tumor (stage IIIC, embryonal cell carcinoma) which proved refractory to conventional PVB combined chemotherapy. He was then treated with an ultra high-dose chemotherapy consisting of carboplatin (1.5 g/m2) and etoposide (1.3 g/m2), followed by the transplantation of peripheral blood stem cells (PBSCT) with a total of 1.9 x 10(5)/kg granulocyte colony-forming cells (CFU-GM). Because he developed lung metastasis, escalated doses of carboplatin (2.0 g/m2), and etoposide (1.8 g/m2) combined with cyclophosphamide (7.0 g/m2) were given with peripheral blood stem cell transplant of 3.2 x 10(5)/kg CFU-GM. He has remained free of any recurrence without maintenance therapy.
一名35岁男性患有晚期非精原细胞性生殖细胞肿瘤（IIIC期，胚胎细胞癌），事实证明其对传统的顺铂-长春新碱-博来霉素联合化疗无效。随后他接受了由卡铂（1.5 g/m²）和依托泊苷（1.3 g/m²）组成的超高剂量化疗，接着进行了外周血干细胞移植（PBSCT），共移植1.9×10⁵/kg粒细胞集落形成细胞（CFU-GM）。由于他出现了肺转移，于是给予了递增剂量的卡铂（2.0 g/m²）、依托泊苷（1.8 g/m²）并联合环磷酰胺（7.0 g/m²），同时进行了3.2×10⁵/kg CFU-GM的外周血干细胞移植。他未经维持治疗，至今未出现任何复发情况。
