Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine.

作者信息

Cardona V M, Ayi A I, Aubertin A M, Guedj R

机构信息

Laboratoire de Chimie Bio-Organique CNRS ESA 6001, Université de Nice-Sophia Antipolis, Faculté des Sciences, Nice, France.

出版信息

Antiviral Res. 1999 Jul;42(3):189-96. doi: 10.1016/s0166-3542(99)00021-2.

DOI:10.1016/s0166-3542(99)00021-2

PMID:10443531

Abstract

Phosphate and H-phosphonate derivatives of anti-HIV nucleoside analogues (AZT and d4T) were prepared as potential prodrugs of the bio-active free nucleotide and they were evaluated for their inhibitory effects on the replication of HIV-1 in several cell culture systems. One compound exhibited an important anti-HIV-1 activity and proved to be significantly more efficient than the parent nucleoside.

摘要

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