Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine.
作者信息
Cardona V M, Ayi A I, Aubertin A M, Guedj R
机构信息
Laboratoire de Chimie Bio-Organique CNRS ESA 6001, Université de Nice-Sophia Antipolis, Faculté des Sciences, Nice, France.
出版信息
Antiviral Res. 1999 Jul;42(3):189-96. doi: 10.1016/s0166-3542(99)00021-2.
Abstract
Phosphate and H-phosphonate derivatives of anti-HIV nucleoside analogues (AZT and d4T) were prepared as potential prodrugs of the bio-active free nucleotide and they were evaluated for their inhibitory effects on the replication of HIV-1 in several cell culture systems. One compound exhibited an important anti-HIV-1 activity and proved to be significantly more efficient than the parent nucleoside.
摘要
相似文献
1
Synthesis and anti-HIV activity of some novel arylphosphate and H-phosphonate derivatives of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine.
Antiviral Res. 1999 Jul;42(3):189-96. doi: 10.1016/s0166-3542(99)00021-2.
2
Synthesis and anti-HIV activity of beta-D-3'-azido-2',3'-unsaturated nucleosides and beta-D-3'-azido-3'-deoxyribofuranosylnucleosides.β-D-3'-叠氮基-2',3'-不饱和核苷和β-D-3'-叠氮基-3'-脱氧呋喃核糖核苷的合成及其抗HIV活性
Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1707-27. doi: 10.1080/15257770500267170.
3
Synthesis of 5-alkynylated d4T analogues as potential HIV-1 reverse transcriptase inhibitors.作为潜在的HIV-1逆转录酶抑制剂的5-炔基化d4T类似物的合成。
J Enzyme Inhib Med Chem. 2004 Dec;19(6):511-9. doi: 10.1080/14756360412331280527.
4
Synthesis and antiviral activity of some 5'-N-phthaloyl-3'-azido-2',3'-dideoxythymidine analogues.一些5'-N-邻苯二甲酰基-3'-叠氮基-2',3'-二脱氧胸苷类似物的合成与抗病毒活性
Antivir Chem Chemother. 2003 May;14(3):139-44. doi: 10.1177/095632020301400303.
5
Anti-HIV activity of novel phosphonate derivatives of AZT, d4T, and ddA.齐多夫定（AZT）、司他夫定（d4T）和双脱氧腺苷（ddA）新型膦酸酯衍生物的抗HIV活性
Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):767-9. doi: 10.1081/NCN-100002426.
6
Uncharged AZT and D4T derivatives of phosphonoformic and phosphonoacetic acids as anti-HIV pronucleosides.膦甲酸和膦乙酸的不带电荷的叠氮胸苷（AZT）及双脱氧胸苷（D4T）衍生物作为抗HIV前体核苷。
J Med Chem. 2004 Jul 1;47(14):3606-14. doi: 10.1021/jm0310176.
7
New lipophilic derivatives of AZT and d4T 5'-phosphonates.齐多夫定（AZT）和司他夫定（d4T）5'-膦酸酯的新型亲脂性衍生物。
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):981-5. doi: 10.1081/NCN-120022718.
8
Novel approaches for designing 5'-O-ester prodrugs of 3'-azido-2', 3'-dideoxythymidine (AZT).设计3'-叠氮基-2'，3'-双脱氧胸苷（AZT）5'-O-酯前药的新方法。
Curr Med Chem. 2000 Oct;7(10):995-1039. doi: 10.2174/0929867003374372.
9
10
Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.新型胸苷类似物2',3'-二脱氢-3'-脱氧-4'-乙炔基胸苷的细胞内代谢及其抗人免疫缺陷病毒活性的持久性
Antimicrob Agents Chemother. 2007 Nov;51(11):3870-9. doi: 10.1128/AAC.00692-07. Epub 2007 Aug 27.
Zotero 插件