胃食管反流病中食管酸暴露的模式会影响疾病的严重程度。
The pattern of esophageal acid exposure in gastroesophageal reflux disease influences the severity of the disease.
作者信息
Campos G M, Peters J H, DeMeester T R, Oberg S, Crookes P F, Mason R J
机构信息
Department of Surgery, University of Southern California School of Medicine, Los Angeles 90033-4612, USA.
出版信息
Arch Surg. 1999 Aug;134(8):882-7; discussion 887-8. doi: 10.1001/archsurg.134.8.882.
HYPOTHESIS
There is an independent association between the different patterns of esophageal acid exposure in gastroesophageal reflux disease and the severity of the disease.
DESIGN
Case-comparison study.
SETTING
Department of surgery at a university hospital.
PATIENTS
A group of 401 patients with increased esophageal acid exposure divided into 4 groups according to the pattern of reflux: postprandial (n = 41), upright (n = 74), supine (n = 129), and bipositional (n = 157).
MAIN OUTCOME MEASURES
The prevalence of mucosal injury and the status of the lower esophageal sphincter and esophageal motility were assessed in each group.
RESULTS
The likelihood of having indicators of the severity of gastroesophageal reflux disease increases progressively from postprandial to upright, supine, and bipositional reflux.
CONCLUSIONS
The pattern of esophageal acid exposure in gastroesophageal reflux disease is an objective predictor of the severity of disease and could be used for therapeutic decisions.
假设
胃食管反流病中食管酸暴露的不同模式与疾病严重程度之间存在独立关联。
设计
病例对照研究。
地点
一所大学医院的外科。
患者
一组401例食管酸暴露增加的患者，根据反流模式分为4组：餐后反流组（n = 41）、直立位反流组（n = 74）、仰卧位反流组（n = 129）和双体位反流组（n = 157）。
主要观察指标
评估每组黏膜损伤的发生率以及食管下括约肌和食管动力状况。
结果
从餐后反流到直立位反流、仰卧位反流和双体位反流，胃食管反流病严重程度指标出现的可能性逐渐增加。
结论
胃食管反流病中食管酸暴露模式是疾病严重程度的客观预测指标，可用于治疗决策。
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