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[轴型食管裂孔疝——有无反流性食管炎患者食管动力障碍与病理性反流的相关性]

[Axial hiatal hernia--correlation of motility disorders and pathological reflux in the esophagus in patients with and without reflux esophagitis].

作者信息

Benz C, Jakobs R, Riemann J F

机构信息

Medizinische Klinik C des Klinikums der Stadt Ludwigshafen/Rhein.

出版信息

Z Gastroenterol. 1994 Jan;32(1):12-5.

PMID:8147035
Abstract

Hiatal hernia is a very common finding in esophagogastroduodenoscopy (EGD). Only some patients with hiatal hernia suffer from gastroesophageal reflux disease (GERD), defined by pathological 24-h-pH-metry, while almost all patients with GERD do have hiatal hernia. To work out the differences in possible motility disorders and in a pathologic acid reflux we examined 92 patients with hiatal hernia by means of manometry and 24-h-pH-metry of the esophagus. A motility disorder of the tubular esophagus in the patients with GERD (with or without reflux esophagitis) was significantly more common than in patients without GERD (p = 0.006). In most cases it was an esophageal hypomotility. There is no significant difference in the basal pressure of the lower esophageal sphincter (LES) between the two groups. We conclude that besides other factors which impair esophageal clearance function a motility disorder of the tubular esophagus is the main cause for the development of GERD in the patients with hiatal hernia. A lowered pressure of the LES seems not to play a major role in the etiology of reflux esophagitis.

摘要

食管裂孔疝在食管胃十二指肠镜检查(EGD)中是非常常见的发现。只有一些食管裂孔疝患者患有胃食管反流病(GERD),这是由病理性24小时pH监测所定义的,而几乎所有GERD患者确实都有食管裂孔疝。为了找出可能的动力障碍和病理性酸反流的差异,我们通过食管测压和24小时pH监测对92例食管裂孔疝患者进行了检查。GERD患者(有或无反流性食管炎)的管状食管动力障碍比无GERD患者明显更常见(p = 0.006)。在大多数情况下,这是食管动力不足。两组之间食管下括约肌(LES)的基础压力没有显著差异。我们得出结论,除了其他损害食管清除功能的因素外,管状食管动力障碍是食管裂孔疝患者发生GERD的主要原因。LES压力降低似乎在反流性食管炎的病因中不起主要作用。

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