Pahapill P A, Levy R, Dostrovsky J O, Davis K D, Rezai A R, Tasker R R, Lozano A M
Department of Surgery, University of Toronto, Ontario, Canada.
Ann Neurol. 1999 Aug;46(2):249-52. doi: 10.1002/1531-8249(199908)46:2<249::aid-ana15>3.0.co;2-c.
Six patients undergoing stereotactic procedures for essential tremor received microinjections of muscimol (a gamma-aminobutyric acid-A [GABA(A)] agonist) into the ventralis intermedius thalamus in areas where tremor-synchronous cells were identified electrophysiologically with microelectrode recordings and where tremor reduction occurred with electrical microstimulation. Injections of muscimol but not saline consistently reduced tremor in each patient. The effect had a mean latency of 7 minutes and lasted an average of 9 minutes. We propose that GABA-mediated thalamic neuronal inhibition may represent a mechanism underlying the effectiveness of surgery for tremor and that GABA analogues could potentially be used therapeutically.
六名因特发性震颤接受立体定向手术的患者，在腹中间核丘脑区域接受了微量注射蝇蕈醇（一种γ-氨基丁酸-A [GABA(A)] 激动剂），这些区域通过微电极记录在电生理上识别出震颤同步细胞，并且通过微电刺激可减轻震颤。注射蝇蕈醇而非生理盐水能持续减轻每位患者的震颤。这种效果的平均潜伏期为7分钟，平均持续9分钟。我们认为，GABA介导的丘脑神经元抑制可能是震颤手术有效性的潜在机制，并且GABA类似物可能具有治疗用途。
