Ogawa T, Tsurusako Y, Kimura N, Nishioka S, Akagi H, Nishizaki K, Nishioka K, Rutka J
Department of Otolaryngology, Okayama University Medical School, Japan.
Acta Otolaryngol Suppl. 1999;540:72-6. doi: 10.1080/00016489950181242.
The serum concentrations of three separate tumor markers, squamous cell carcinoma antigen (SCC Ag), carcinoembryonic antigen (CEA) and Cyfra 21-1 were clinically correlated in 86 randomly selected patients with squamous cell carcinoma involving the head and neck. Positive findings for each tumor marker were totalled and statistically analysed. The upper limits of normal for SCC Ag, CEA and Cyfra 21-1 were set at 1.5, 2.5 and 2.0 ng/ml, respectively. Positivity rates were 20.6% for SCC Ag, 14.0% for CEA and 41.7% for Cyfra 21-1. Elevated Cyfra 21-1 concentrations correlated somewhat with age, whereas elevated CEA levels correlated with the site of tumor involvement. Overall, Cyfra 21-1 appeared to be the most useful marker in head and neck squamous cell carcinoma.
对86例随机选取的头颈部鳞状细胞癌患者，临床上对三种不同肿瘤标志物——鳞状细胞癌抗原（SCC Ag）、癌胚抗原（CEA）和细胞角蛋白19片段（Cyfra 21-1）的血清浓度进行了相关性研究。汇总并统计分析了每种肿瘤标志物的阳性结果。SCC Ag、CEA和Cyfra 21-1的正常上限分别设定为1.5、2.5和2.0 ng/ml。SCC Ag的阳性率为20.6%，CEA为14.0%，Cyfra 21-1为41.7%。Cyfra 21-1浓度升高与年龄有一定相关性，而CEA水平升高与肿瘤累及部位相关。总体而言，Cyfra 21-1似乎是头颈部鳞状细胞癌中最有用的标志物。
