低剂量的ipsapirone可增加正常男性和女性受试者的生长激素分泌，但不增加催产素分泌。
Low doses of ipsapirone increase growth hormone but not oxytocin secretion in normal male and female subjects.
作者信息
Newman M E, Li Q, Gelfin Y, Van de Kar L D, Lerer B
机构信息
Biological Psychiatry Laboratory, Hadassah University Hospital, Jerusalem, Israel.
出版信息
Psychopharmacology (Berl). 1999 Jul;145(1):99-104. doi: 10.1007/s002130051037.
OBJECTIVE
The present study investigated whether administration of a 5-HT1A receptor agonist would increase growth hormone (GH) and oxytocin levels in normal human subjects, and whether the responses would be modified according to the age and gender of the subjects.
METHODS
Ipsapirone (0.3 mg/kg body weight), or placebo was administered to 30 normal subjects (14 males, 19-74 years and 16 females, 22-69 years) using a randomized, double blind design.
RESULTS
Stimulation of GH secretion by ipsapirone was significantly greater in male compared to female subjects, with no apparent effect of age. Oxytocin secretion was not stimulated by ipsapirone compared to placebo in any of the groups.
CONCLUSIONS
The effects of gender and age on the degree of stimulation of GH secretion by 5-HT1A agonists in human subjects differ from their effects on secretion of the hormones ACTH and cortisol. A higher dose of ipsapirone is required to stimulate oxytocin secretion in normal human subjects.
目的
本研究调查了给予5-羟色胺1A受体激动剂是否会增加正常人类受试者的生长激素（GH）和催产素水平，以及这些反应是否会根据受试者的年龄和性别而改变。
方法
采用随机、双盲设计，对30名正常受试者（14名男性，年龄19 - 74岁；16名女性，年龄22 - 69岁）给予伊沙匹隆（0.3 mg/kg体重）或安慰剂。
结果
与女性受试者相比，伊沙匹隆对男性受试者生长激素分泌的刺激作用显著更强，年龄无明显影响。与安慰剂相比，伊沙匹隆在任何组中均未刺激催产素分泌。
结论
性别和年龄对5-羟色胺1A激动剂刺激人类受试者生长激素分泌程度的影响不同于它们对促肾上腺皮质激素（ACTH）和皮质醇分泌的影响。在正常人类受试者中，需要更高剂量的伊沙匹隆来刺激催产素分泌。
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