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膀胱神经通路中的神经元型一氧化氮合酶。

Neuronal nitric oxide synthase in the neural pathways of the urinary bladder.

作者信息

Zhou Y, Ling E A

机构信息

Department of Experimental Surgery, Singapore General Hospital, Singapore.

出版信息

J Anat. 1999 May;194 ( Pt 4)(Pt 4):481-96. doi: 10.1046/j.1469-7580.1999.19440481.x.

Abstract

Nitric oxide (NO) is a unique biological messenger molecule. It serves, in part, as a neurotransmitter in the central and peripheral nervous systems. Neurons containing NO have been identified histochemically by the presence of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) reactivity or immunohistochemically by the antibody for neuronal NO synthase (n-NOS). Previous histochemical or pharmacological studies have raised the possibility that NO may play an important role in the neural pathways of the lower urinary tract. There is also considerable evidence to suggest that n-NOS is plastic and could be upregulated following certain lesions in the lower urinary tract. The present review summarises the distribution of n-NOS containing neurons innervating the urinary bladder and the changes of the enzyme expression in some experimentally induced pathological conditions.

摘要

一氧化氮(NO)是一种独特的生物信使分子。它在中枢和外周神经系统中部分地充当神经递质。通过烟酰胺腺嘌呤二核苷酸磷酸黄递酶(NADPH-d)反应性的存在,已通过组织化学方法鉴定出含有NO的神经元;或者通过针对神经元型一氧化氮合酶(n-NOS)的抗体,通过免疫组织化学方法鉴定出此类神经元。先前的组织化学或药理学研究提出了NO可能在下尿路神经通路中起重要作用的可能性。也有大量证据表明n-NOS具有可塑性,并且在下尿路某些损伤后可能会上调。本综述总结了支配膀胱的含n-NOS神经元的分布以及在一些实验诱导的病理条件下该酶表达的变化。

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Nitric oxide in neurodegeneration.神经退行性变中的一氧化氮
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