树突状抑制使海马CA1神经元的时间总和正常化。

Dendritic lh normalizes temporal summation in hippocampal CA1 neurons.

作者信息

Magee J C

机构信息

Neuroscience Center, Louisiana State University Medical Center, 2020 Gravier St., New Orleans, Louisiana 70112, USA.

出版信息

Nat Neurosci. 1999 Jun;2(6):508-14. doi: 10.1038/9158.

DOI:10.1038/9158

PMID:10448214

Abstract

Most mammalian central neurons receive synaptic input over complicated dendritic arbors. Therefore, timing of synaptic information should vary with synapse location. However, I report that temporal summation at CA1 pyramidal somata does not depend on the location of synaptic input. This spatial normalization of temporal integration requires a dendritic hyperpolarization-activated current (lh). Shaping of synaptic activity by deactivating a nonuniform lh could counterbalance filtering by dendrites and effectively remove location-dependent variability in temporal integration, thus enhancing synchronization of neuronal populations and functional capabilities of the hippocampal CA1 region.

摘要

大多数哺乳动物的中枢神经元通过复杂的树突分支接收突触输入。因此，突触信息的时间应该随突触位置而变化。然而，我报告称，CA1锥体神经元胞体处的时间总和并不取决于突触输入的位置。这种时间整合的空间归一化需要一种树突超极化激活电流（lh）。通过使不均匀的lh失活来塑造突触活动，可以抵消树突的滤波作用，并有效消除时间整合中位置依赖性的变异性，从而增强神经元群体的同步性和海马CA1区的功能能力。