Devay P, McGehee D S, Yu C R, Role L W
Columbia University, College of Physicians and Surgeons, Department of Anatomy and Cell Biology and The Center for Neurobiology and Behavior, 1051 Riverside Drive, New York, New York 10032, USA.
Nat Neurosci. 1999 Jun;2(6):528-34. doi: 10.1038/9183.
Neuronal differentiation and development of synaptic specializations are strongly influenced by cellular interactions. We compared the effects of interaction with distinct autonomic targets on the molecular and biophysical differentiation of 'upstream' neuron-neuron synapses. Contact with cardiac tissue induced expression of nicotinic receptor channels (nAChRs) distinct from those induced by renal tissue in presynaptic autonomic neurons. The kinetics of cholinergic currents at interneuronal synapses are dictated by the peripheral target contacted. Analysis of the nAChR channel subtypes and subunits in individual neurons demonstrated that the profile of transmitter receptors expressed at mature neuron-neuron synapses develops from the convergent influences of input-derived (anterograde) and target-specific (retrograde) signals.
神经元的分化以及突触特化的发育受到细胞间相互作用的强烈影响。我们比较了与不同自主神经靶标相互作用对“上游”神经元-神经元突触分子和生物物理分化的影响。与心脏组织的接触诱导了突触前自主神经元中不同于肾组织诱导产生的烟碱受体通道(nAChRs)的表达。中间神经元突触处胆碱能电流的动力学由所接触的外周靶标决定。对单个神经元中nAChR通道亚型和亚基的分析表明,成熟神经元-神经元突触处表达的递质受体谱是由输入源(顺行)和靶标特异性(逆行)信号的汇聚影响所形成的。