Limmroth V, Katsarava Z, Diener H C
Department of Neurology, University Hospital Essen, Germany.
Cephalalgia. 1999 Jul;19(6):545-51. doi: 10.1046/j.1468-2982.1999.019006545.x.
Acetylsalicylic acid (ASA) is used to treat a broad range of symptoms and disorders. Since its discovery in 1897, it has been used to treat fever and rheumatic pain, to inhibit the formation of thrombocytes, to prevent myocardial ischemia and strokes, and as preventive medication against neoplasms. ASA is best known, however, as a headache medication. For this function alone, ASA underwent an evolution: from powder to tablet to effervescent and chewable tablets. In addition to these oral formulations, an injectable form was developed in the 1970s for intravenous and intramuscular application. Furthermore, coated (slow-releasing) tablets are now used in the prophylactic treatment of migraine. The various forms of ASA used to treat headache are discussed and the controlled studies conducted to evaluate ASA's efficacy in headache treatment are summarized.
乙酰水杨酸（ASA）用于治疗多种症状和疾病。自1897年被发现以来，它一直被用于治疗发热和风湿性疼痛、抑制血小板形成、预防心肌缺血和中风，以及作为预防肿瘤的药物。然而，ASA最为人所知的是作为一种头痛药物。仅就这一功能而言，ASA经历了一次演变：从粉末到片剂，再到泡腾片和咀嚼片。除了这些口服制剂外，20世纪70年代还开发了一种注射剂，用于静脉和肌肉注射。此外，包衣（缓释）片现在用于偏头痛的预防性治疗。本文讨论了用于治疗头痛的各种形式的ASA，并总结了为评估ASA在头痛治疗中的疗效而进行的对照研究。
