Robinson L A
Department of Surgery, University of South Florida College of Medicine, Tampa, USA.
Surg Oncol Clin N Am. 1999 Jul;8(3):565-76, xi.
Accurate staging of malignancies is essential to guide the clinician in selecting the most appropriate therapy. Metastases to bone suggested by radionuclide bone scans must be proven histologically because of the high frequency of false-positive results. If the plain bone radiographs, however, are normal and there are no localizing symptoms, precise biopsy of the area of bone scan abnormality is usually difficult and time-consuming. The recently described intraoperative use of the hand-held gamma probe now allows for great accuracy and sensitivity in the radioisotope-guided open biopsy of clinically suspected bone metastases.
恶性肿瘤的准确分期对于指导临床医生选择最合适的治疗方法至关重要。由于假阳性结果的发生率较高，放射性核素骨扫描提示的骨转移必须通过组织学证实。然而，如果平片骨片正常且没有定位症状，对骨扫描异常区域进行精确活检通常既困难又耗时。最近描述的术中使用手持式γ探测器，现在在临床怀疑的骨转移的放射性同位素引导下开放活检中具有很高的准确性和敏感性。
