Ji J, Porjesz B, Begleiter H, Chorlian D
State University of New York, Health Science Center at Brooklyn 11203, USA.
Brain Topogr. 1999 Summer;11(4):315-27. doi: 10.1023/a:1022262721343.
To examine the topographic relationship of P3(00) between the visual and auditory modalities, especially to examine whether there are any modality-specific hemispheric differences of P3 in normal adults.
The P3s were recorded from the same 41 normal right-handed males between the ages of 20 and 33 in both a typical auditory oddball task and a visual oddball paradigm with novel stimuli, with an extensive set of 61 scalp electrodes. In addition to the visual comparison and quantitative assessment of current source density (CSD) maps between the two modalities, canonical correlation analyses on the P3 raw amplitudes and examination of interaction effects of modality x location on both raw and normalized P3 data were performed.
The canonical correlation between modalities was generally high, especially at the left parietal brain region. There were no significant hemispheric effects in anterior brain but significant left-greater-than-right hemispheric effects in posterior brain regions in both modalities; modality-specific hemispheric effect was observed only at the parietal region. Strong surface current density activities were observed in the midline parietal-occipital area, and left and right boundary areas of temporal and inferior frontal region.
The topographic similarities between P3s recorded in the visual and auditory modality outnumber the differences. Combining data from CSD assessments and profile analysis of P3 topography support the hypothesis of multiple generators of P3 that are differentially active in processing stimuli from different sensory modalities and are not symmetrically distributed between the two hemispheres.
研究视觉和听觉模态下P3(00)的地形关系，特别是检查正常成年人中P3是否存在特定模态的半球差异。
对41名年龄在20至33岁之间的正常右利手男性，在典型的听觉oddball任务和具有新颖刺激的视觉oddball范式中，使用61个头皮电极记录P3。除了对两种模态之间的电流源密度（CSD）图进行视觉比较和定量评估外，还对P3原始振幅进行了典型相关分析，并对原始和标准化P3数据上的模态x位置的交互作用进行了检查。
模态之间的典型相关性通常较高，尤其是在左顶叶脑区。在前脑没有显著的半球效应，但在两种模态的后脑区域都有显著的左半球大于右半球的效应；仅在顶叶区域观察到特定模态的半球效应。在中线顶枕区以及颞叶和额下回的左右边界区域观察到强烈的表面电流密度活动。
视觉和听觉模态中记录的P3之间的地形相似性多于差异。结合CSD评估数据和P3地形的轮廓分析支持了P3多发生器的假设，这些发生器在处理来自不同感觉模态的刺激时具有不同的活性，并且在两个半球之间分布不对称。
