Khafif A, Khafif R A, Attie J N
Department of Otolaryngology & Head and Neck Surgery, Kaplan Hospital, Rehovot, Israel.
Head Neck. 1999 Sep;21(6):506-11. doi: 10.1002/(sici)1097-0347(199909)21:6<506::aid-hed2>3.0.co;2-m.
Hürthle cell carcinoma of the thyroid is a variant of follicular carcinoma, which has been considered by many as a more aggressive disease than the usual well-differentiated carcinoma of the thyroid. Others, however, have found Hürthle cell carcinoma to be a low-grade malignancy with little morbidity or mortality.
This is a retrospective report on all patients with Hürthle cell carcinoma diagnosed during the years 1951-1997 by the authors. The behavior of the disease and results of treatment were analyzed biostatistically and the outcome was compared with that of patients with pure follicular carcinoma treated during the same period.
Forty-two patients were diagnosed with Hürthle cell carcinoma and 153 with follicular carcinoma during this period (2.8% and 10.3% of all differentiated carcinomas of the thyroid, respectively). The rate of local recurrence and disease-related mortality were both 9.5%, compared with 3.2% & 15.7%, respectively, for the follicular cancers. There was a trend for better outcome in patients younger than 55 years of age, in patients with tumors under 4 cm in size, and in patients treated by total thyroidectomy. Distant metastases occurred in four patients (9.5%) and were the cause of disease-related mortality in three.
When treated assertively, Hürthle cell carcinoma of the thyroid, an oncocytic variant of follicular carcinoma, has a favorable outcome, similar to that of pure follicular carcinoma. Uniting those two entities in a future classification and reporting should be considered.
甲状腺嗜酸性细胞癌是滤泡癌的一种变体，许多人认为它比常见的甲状腺高分化癌更具侵袭性。然而，其他人发现甲状腺嗜酸性细胞癌是一种低级别恶性肿瘤，发病率和死亡率都很低。
这是一篇关于作者在1951年至1997年间诊断出的所有甲状腺嗜酸性细胞癌患者的回顾性报告。对疾病行为和治疗结果进行了生物统计学分析，并将结果与同期接受治疗的纯滤泡癌患者的结果进行了比较。
在此期间，42例患者被诊断为甲状腺嗜酸性细胞癌，153例为滤泡癌（分别占所有甲状腺分化癌的2.8%和10.3%）。局部复发率和疾病相关死亡率均为9.5%，而滤泡癌分别为3.2%和15.7%。年龄小于55岁、肿瘤大小小于4 cm以及接受全甲状腺切除术治疗的患者预后有更好的趋势。4例患者（9.5%）发生远处转移，其中3例是疾病相关死亡的原因。
积极治疗时，甲状腺嗜酸性细胞癌（滤泡癌的一种嗜酸细胞变体）的预后良好，与纯滤泡癌相似。在未来的分类和报告中应考虑将这两种实体合并。
