Pitman K T, Johnson J T
Department of Otolaryngology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Suite 500, Pittsburgh, PA 15213, USA.
Head Neck. 1999 Sep;21(6):560-5. doi: 10.1002/(sici)1097-0347(199909)21:6<560::aid-hed10>3.0.co;2-q.
Squamous cell carcinoma (SCC) of the upper aerodigestive tract rarely metastasizes to the skin. This study was designed to review the incidence of skin metastases, to identify associated risk factors, and to investigate the prognostic significance of skin metastases.
A cohort of 2491 patients treated for SCC originating in the upper aerodigestive tract were evaluated retrospectively. Patients who developed skin metastases were evaluated with respect to tumor stage, treatment, and outcome. Patients with skin metastases were compared with patients who developed distant metastases at other sites and with those who did not develop distant metastases.
Skin metastases developed in 19 (0.763%) patients. The median time to occurrence was 6 months. Ninety percent of patients died of disease within a median of 3 months (1 to 16 months) following diagnosis. The development of skin metastasis is most closely related to the presence of two or more cervical metastases and/or extracapsular spread of tumor in the cervical metastases. Similar risk factors were identified for the development of distant metastases to other sites.
Metastasis to skin is a rare occurrence which has prognostic significance similar to distant metastasis to other areas.
上消化道鳞状细胞癌（SCC）很少转移至皮肤。本研究旨在回顾皮肤转移的发生率，确定相关危险因素，并探讨皮肤转移的预后意义。
对2491例接受上消化道SCC治疗的患者进行回顾性评估。对发生皮肤转移的患者进行肿瘤分期、治疗及预后评估。将发生皮肤转移的患者与发生其他部位远处转移的患者以及未发生远处转移的患者进行比较。
19例（0.763%）患者发生皮肤转移。发生的中位时间为6个月。90%的患者在诊断后的中位3个月（1至16个月）内死于疾病。皮肤转移的发生与两个或更多颈部转移灶的存在和/或颈部转移灶中肿瘤的包膜外扩散最为密切相关。在发生其他部位远处转移方面也发现了类似的危险因素。
皮肤转移是一种罕见情况，其预后意义与其他部位的远处转移相似。
