Aloi F, Albertazzi D, Pippione M
Department of Dermatology, University of Turin, Italy.
Dermatology. 1999;199(1):54-6. doi: 10.1159/000018179.
We describe two examples of an unusual variant of dermatofibroma (DF) in which areas of granular cells were a prominent feature. The diagnosis of DF was confirmed by immunohistochemistry and by ultrastructural studies. Granular cell changes can be observed in numerous benign and malignant cutaneous tumors of different cellular lineage. Cellular granularity is a nonspecific phenomenon characterized by intracytoplasmic accumulation of lysosomes and may cause diagnostic difficulties. Traumatic factors may be involved in the pathogenesis of cellular granularity.
我们描述了两例皮肤纤维瘤（DF）的不寻常变体，其中颗粒细胞区域是一个突出特征。通过免疫组织化学和超微结构研究证实了DF的诊断。在许多不同细胞谱系的良性和恶性皮肤肿瘤中都可观察到颗粒细胞变化。细胞颗粒化是一种非特异性现象，其特征是溶酶体在细胞质内积聚，可能会导致诊断困难。创伤因素可能参与了细胞颗粒化的发病机制。
