Soyer H P, Metze D, Kerl H
Department of Dermatology, University of Graz, Austria.
Am J Dermatopathol. 1997 Apr;19(2):168-73. doi: 10.1097/00000372-199704000-00011.
We herein describe the histopathologic findings of an otherwise stereotypical dermatofibroma replete with granular cells. The histopathologic diagnosis of dermatofibroma was underlined by immunohistochemical findings and ultrastructural examination. Cellular granularity is the result of cytoplasmic accumulation of lysosomal structures and can be observed not only in conventional granular cell tumor but in a variety of benign and malignant cutaneous neoplasms. Granular cell dermatofibroma represents a hitherto undescribed variant of dermatofibroma that can be added to the broad histopathologic spectrum of this benign fibrohistiocytic proliferation.
我们在此描述了一例典型的富含颗粒细胞的皮肤纤维瘤的组织病理学发现。免疫组化结果和超微结构检查进一步明确了皮肤纤维瘤的组织病理学诊断。细胞颗粒是溶酶体结构在细胞质中积累的结果，不仅在传统的颗粒细胞瘤中可以观察到，在各种良性和恶性皮肤肿瘤中也能观察到。颗粒细胞性皮肤纤维瘤代表了一种迄今为止尚未描述的皮肤纤维瘤变体，可补充到这种良性纤维组织细胞增生的广泛组织病理学谱中。
