Eke T, Thompson J R
Sub-Committee Royal College of Ophthalmologists, London, UK.
Eye (Lond). 1999 Apr;13 ( Pt 2):196-204. doi: 10.1038/eye.1999.50.
To describe the adverse events associated with local anaesthesia (LA) for intraocular surgery.
An observational study of practice of LA in the whole of the United Kingdom was conducted over 3 months in late 1996. Staff in all ophthalmology theatres in the National Health Service were invited to report every LA given for the purpose of intraocular surgery during the first week, and thereafter to report adverse events only.
During the first week, the reported incidence of all adverse events within the orbit was 2.7%, and for 'systemic' adverse events it was 0.9%. Serious adverse events were reported in association with all LA techniques. In 3 months, 18 events were described as 'life-threatening' by respondents, and further patients were reported to have had epileptic fits or were transferred directly from the operating theatre to an intensive care unit. The voluntary nature of the survey introduces some bias from under-reporting, making the incidence of these severe events difficult to assess. Reported incidence of severe 'systemic' adverse events was similar for all LA techniques.
Serious adverse events were reported in association with with all LA techniques. This implies that we should be prepared for such events in all patients who have intraocular surgery.
描述与眼内手术局部麻醉（LA）相关的不良事件。
1996年末对整个英国LA的使用情况进行了为期3个月的观察性研究。邀请国民健康服务体系中所有眼科手术室的工作人员报告第一周内用于眼内手术的每一次LA，此后仅报告不良事件。
在第一周，眼眶内所有不良事件的报告发生率为2.7%，“全身”不良事件的发生率为0.9%。与所有LA技术相关均报告有严重不良事件。在3个月内，有18起事件被受访者描述为“危及生命”，另有患者报告发生癫痫发作或直接从手术室转入重症监护病房。调查的自愿性质导致报告不足，存在一定偏差，使得这些严重事件的发生率难以评估。所有LA技术的严重“全身”不良事件报告发生率相似。
与所有LA技术相关均报告有严重不良事件。这意味着我们应对所有接受眼内手术的患者发生此类事件做好准备。
