Murphy W M, Soloway M S, Lin C J
Acta Cytol. 1978 Nov-Dec;22(6):550-4.
Morphologic changes induced by thio-TEPA were examined in animals with chemically induced neoplasms. Both toxic and metabolic effects were documented. Degeneration, vacuolization and increased exfoliation (toxic) were most prominent, occurred within 48 hours of exposure, and tended to subside after removal of the drug. Nuclear changes (metabolic) were rare and occurred late. Neither toxic nor metabolic effects were specific for thio-TEPA: both could be detected in control animals receiving saline. The metabolic effects of thio-TEPA are not sufficiently widespread to prevent tumor growth.
在化学诱导肿瘤的动物中检查了硫替派引起的形态学变化。记录了毒性和代谢作用。变性、空泡化和脱屑增加（毒性作用）最为显著，在接触后48小时内出现，停药后往往消退。核变化（代谢作用）很少见且出现较晚。硫替派的毒性和代谢作用都不具有特异性：在接受生理盐水的对照动物中均可检测到。硫替派的代谢作用分布不够广泛，无法阻止肿瘤生长。
