Zanardo V, Trevisanuto D, Vanin E, Marzari F, Guglielmi A
Department of Pediatrics, University of Padua, Italy.
Pediatr Med Chir. 1999 Jan-Feb;21(1):1-4.
To determine the effect of prolonged dexamethasone therapy on oxygen-dependency clinical phase of prematures with bronchopulmonary dysplasia, we examined a consecutive group of 27 infants (birth weight, < 1500 g and gestational age, < 32 weeks), who remained with a static or deteriorating oxygen-dependency after weaning from the respirator [pre-treatment FiO2, mean +/- SEM over three days (31 +/- 2)%, range (27-73)%]. Twenty five out of 27 infants were weaned from supplemental oxygen during the 42-day steroid treatment period, with a mean (+/- SEM) duration of oxygen supplementation of 16 +/- 4 days. The distribution of the ratios of successive post-treatment FiO2 values with respect to pre-treatment FiO2 shows, on average, a progressive reduction with time. The percentage of the FiO2 decrease is statistically significant at a level of 2 and 3 SD after 3 days and 7 days, respectively and the average FiO2 fall, as function of time, follows an exponential law. It follows that the time spent in oxygen for a single patient may be determined, accounting for the individual severity of pre-treatment FiO2.
为了确定长期地塞米松治疗对支气管肺发育不良早产儿氧依赖临床阶段的影响，我们检查了一组连续的27名婴儿（出生体重<1500克，胎龄<32周），这些婴儿在脱离呼吸机后仍存在持续或恶化的氧依赖[治疗前三天的平均±标准误的吸入氧分数（FiO2）为（31±2）%，范围为（27 - 73）%]。在为期42天的类固醇治疗期间，27名婴儿中有25名脱离了补充氧气，平均（±标准误）补充氧气的持续时间为16±4天。治疗后连续的FiO2值与治疗前FiO2值的比率分布显示，平均而言，随着时间的推移逐渐降低。FiO2下降的百分比在第3天和第7天分别在2个标准差和3个标准差水平上具有统计学意义，并且作为时间函数的平均FiO2下降遵循指数规律。由此可以确定单个患者在氧气中的停留时间，同时考虑到治疗前FiO2的个体严重程度。
