[最小剂量地塞米松对小鼠胚胎成纤维细胞体外生长速率的影响]
[The effect of minimal dexamethasone on the rate of growth of mouse embryonic fibroblasts in vitro].
作者信息
Zhu Z
机构信息
Department of Ophthalmology, Zhongshan Hospital, Shanghai Medical University.
出版信息
Zhonghua Yan Ke Za Zhi. 1997 Jul;33(4):304-6.
OBJECTIVE
To study of the relationship between inhibition of the growth rate of mouse embryonic fibroblasts (MEF) and the dosage of dexamethasone.
METHOD
Cell culture.
RESULTS
The effect was observed from 48 to 72 hours after addition of 50 micrograms/ml (0.005%) dexamethasone. In comparison with the control, the number of MEF was cut down by 16%-26%, whereas the addition of dexamethasone between 1 microgram/ml and 10 micrograms/ml (0.0001-0.001%) had no significant effect on the rate of growth of MEF.
CONCLUSION
The minimal dosage of dexamethasone has no significant inhibitory effect on the growth rate of fibroblasts and wound healing.
目的
研究地塞米松剂量与小鼠胚胎成纤维细胞（MEF）生长速率抑制之间的关系。
方法
细胞培养。
结果
添加50微克/毫升（0.005%）地塞米松后48至72小时观察到效果。与对照组相比，MEF数量减少了16% - 26%，而添加1微克/毫升至10微克/毫升（0.0001 - 0.001%）的地塞米松对MEF生长速率无显著影响。
结论
地塞米松的最小剂量对成纤维细胞生长速率和伤口愈合无显著抑制作用。
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