褪黑素抑制新生大鼠体外垂体前叶细胞中促甲状腺激素释放激素刺激的催乳素基因表达
[Melatonin inhibits TRH-stimulating prolactin gene expression of anterior pituitary cells in newborn rat in vitro].
作者信息
Di A, Xu R, Peng S, Shan H, Qian Z
机构信息
Institute of Basic Medical Sciences, Beijing.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1997 Dec;19(6):430-5.
OBJECTIVE AND METHODS
This work was to investigate whether melatonin (MEL) plays a role in the gene expression of prolactin (PRL), by the Method of in situ hybridyzation.
RESULTS
Our results indicated that, at a higher concentration, MEL not only inhibits TRH (thyrotropin releasing hormone) stimulating PRL gene expression of anterior pituitary cell in newborn rat, but also exerts a direct inhibitory effect on PRL gene expression in vitro.
CONCLUSION
These results suggest that MEL may be a regulator of PRL synthesis and secreting in vivo.
目的与方法
本研究旨在通过原位杂交法探讨褪黑素（MEL）是否在催乳素（PRL）基因表达中发挥作用。
结果
我们的结果表明，在较高浓度下，MEL不仅抑制促甲状腺激素释放激素（TRH）刺激新生大鼠垂体前叶细胞的PRL基因表达，而且在体外对PRL基因表达也有直接抑制作用。
结论
这些结果表明，MEL可能是体内PRL合成和分泌的调节因子。
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