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Genetic engineering of doxorubicin production in Streptomyces peucetius: a review.

作者信息

Hutchinson C R, Colombo A L

机构信息

School of Pharmacy and Department of Bacteriology, University of Wisconsin, Madison 53706, USA.

出版信息

J Ind Microbiol Biotechnol. 1999 Jul;23(1):647-52. doi: 10.1038/sj.jim.2900673.

Abstract

The genetics and biochemistry of daunorubicin and doxorubicin production by Streptomyces peucetius is reviewed, with a focus on how such information can be used for the genetic engineering of strains having improved titers of these two antitumor antibiotics.

摘要

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