Hutchinson C R, Colombo A L
School of Pharmacy and Department of Bacteriology, University of Wisconsin, Madison 53706, USA.
J Ind Microbiol Biotechnol. 1999 Jul;23(1):647-52. doi: 10.1038/sj.jim.2900673.
The genetics and biochemistry of daunorubicin and doxorubicin production by Streptomyces peucetius is reviewed, with a focus on how such information can be used for the genetic engineering of strains having improved titers of these two antitumor antibiotics.