Medvedev I O, Dravolina O A, Bespalov A Y
Laboratory of Behavioral Pharmacology, Valdman Institute of Pharmacology, Pavlov Medical University, St. Petersburg, Russia.
Eur J Pharmacol. 1999 Jul 21;377(2-3):183-6. doi: 10.1016/s0014-2999(99)00435-5.
Our previous report suggested that antagonists acting at NMDA receptors attenuate discriminative stimulus effects of naloxone in morphine dependent rats. Nitric oxide (NO) is a putative second messenger which mediates NMDA receptor activation. The present study evaluated behavioral effects of NO synthase inhibitor, 7-nitroindazole in morphine-dependent rats trained to discriminate 0.1 mg/kg naloxone from saline. 7-Nitroindazole did not significantly affect naloxone's discriminative stimulus effects but decreased naloxone-induced weight loss and abolished expression of several withdrawal signs--diarrhea, scream on touch, tremor and 'wet dog'-like shaking suggesting different mechanisms for subjective and somatic components of opioid withdrawal.
我们之前的报告表明，作用于N-甲基-D-天冬氨酸（NMDA）受体的拮抗剂可减弱吗啡依赖大鼠中纳洛酮的辨别性刺激效应。一氧化氮（NO）是一种假定的第二信使，可介导NMDA受体激活。本研究评估了一氧化氮合酶抑制剂7-硝基吲唑对经训练以区分0.1mg/kg纳洛酮和生理盐水的吗啡依赖大鼠的行为影响。7-硝基吲唑并未显著影响纳洛酮的辨别性刺激效应，但减少了纳洛酮引起的体重减轻，并消除了几种戒断症状的表现——腹泻、触摸时尖叫、震颤和“湿狗”样抖动，这表明阿片类药物戒断的主观和躯体成分存在不同机制。
