Guehl D, Bezard E, Dovero S, Boraud T, Bioulac B, Gross C
Basal Gang, Laboratoire de Neurophysiologie, Centre National de la Recherche Scientifique UMR 5543, Universite de Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux Cedex, Cedex, France.
Eur J Neurol. 1999 Sep;6(5):609-11. doi: 10.1046/j.1468-1331.1999.650609.x.
This report describes the case of a 47-year-old woman who developed Parkinson's disease after seven years of professional exposure to trichloroethylene. In the light of this clinical report, mice were intoxicated with trichloroethylene and tyrosine hydroxylase immunoreactivity was used to measure neuronal death in the substantia nigra pars compacta. Treated mice presented significant dopaminergic neuronal death in comparison with control mice (50%). The environmental trichlorethylene pollution, as well as other unspecific neurotoxic solvents, could potentially contribute to the genesis of some cases of Parkinson's disease.
本报告描述了一名47岁女性的病例，该女性在职业接触三氯乙烯七年后患上帕金森病。根据这份临床报告，用三氯乙烯使小鼠中毒，并使用酪氨酸羟化酶免疫反应性来测量黑质致密部的神经元死亡。与对照小鼠相比，接受治疗的小鼠出现了显著的多巴胺能神经元死亡（50%）。环境中的三氯乙烯污染以及其他非特异性神经毒性溶剂可能在某些帕金森病病例的发病中起作用。
