Bobryshev Y V, Konovalov H V, Lord R S
Surgical Professorial Unit, St. Vincent's Hospital, Darlinghurst, Australia.
J Submicrosc Cytol Pathol. 1999 Apr;31(2):179-85.
The present study was undertaken to determine whether dendritic cells contributed to the intimal abnormalities seen in the aortas of chickens infected with Marek's disease. Semithin sections were used to select aortic segments in which the intima was thickened by lymphocytic infiltrates. Ultrathin sections were then examined. Intermingled with lymphocytes within the intimal thickenings were cells with an appearance typical of dendritic cells including long processes and a unique tubulovesicular system. In these cellular processes the tubulovesicular system was hypertrophied with the tubular cisterns characteristically forming concentric cyclical layers. Our observations show that dendritic cells are present in the aortic lesions of Marek's disease and are presumably involved in related immune mechanisms.
本研究旨在确定树突状细胞是否与感染马立克氏病的鸡主动脉内膜异常有关。使用半薄切片选择内膜因淋巴细胞浸润而增厚的主动脉段。然后检查超薄切片。在内膜增厚处与淋巴细胞混合的是具有树突状细胞典型外观的细胞，包括长突起和独特的管泡系统。在这些细胞突起中，管泡系统肥大，管状池特征性地形成同心环状层。我们的观察结果表明，树突状细胞存在于马立克氏病的主动脉病变中，可能参与相关免疫机制。
