[γ-氨基丁酸对雅罗鱼脑微粒体Mg2+-ATP酶的影响]
[Effect of gamma-aminobutyric acid on Mg2+-ATPase of brain microsomes of the fish Abramis brama L].
作者信息
Menzikov S A, Menzikova O V
机构信息
I.D. Papanin Institute of Inland Waters Biology, Russian Academy of Sciences, Borok, Yaroslavl Region.
出版信息
Ukr Biokhim Zh (1999). 1999 Jan-Feb;71(1):109-11.
The influence of the GABA on the Mg(2+)-ATPase from microsomal fraction of fish brain (Abramis brama L.) was investigation. Preincubation of the microsomes with different concentration of GABA (10(-8)-10(-4) M) stimulated Mg(2+)-ATPase activity. This effect of neuromediator is sensitive to picrotoxine (10(-4) M). It was established that Mg(2+)-ATPase activity stimulated by anions (Cl > Br > F), inhibited by SCN- and not effected by HCO3-. The influence of the anions on the Mg(2+)-ATPase is liable to be inhibited by picrotoxine. It was supposed that anion-sensitive Mg(2+)-ATPase is associated functionally with GABAa-receptor.
研究了γ-氨基丁酸（GABA）对鲤科鱼（欧鳊）脑微粒体部分的镁离子-三磷酸腺苷酶（Mg(2+)-ATPase）的影响。用不同浓度的GABA（10(-8)-10(-4)M）对微粒体进行预孵育，刺激了Mg(2+)-ATPase的活性。这种神经递质的作用对印防己毒素（10(-4)M）敏感。已确定Mg(2+)-ATPase的活性受阴离子（Cl＞Br＞F）刺激，受硫氰酸盐抑制，不受碳酸氢根影响。阴离子对Mg(2+)-ATPase的影响易被印防己毒素抑制。据推测，对阴离子敏感的Mg(2+)-ATPase在功能上与GABAa受体相关。
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