Jung D Y, Kim J W, Lee S K, Lee W W
Department of Dermatology, Maryknoll Hospital, Pusan, Korea.
J Dermatol. 1999 Jul;26(7):448-51. doi: 10.1111/j.1346-8138.1999.tb02024.x.
A 24-year-old man showed recurrent necrotic papulovesicles of the face. The cutaneous lesions started with erythema, followed by vesicles, necrosis, and crusting, and leaving depressed scars. Light avoidance did not prevent the development of the lesions. Histologic examination revealed lymphoproliferative lesions confined to the skin. Latent Epstein-Barr virus (EBV) infection was detected in the lymphoid cells from the skin lesions by in situ hybridization. A moderate to high dosage of corticosteroids suppressed the development of new skin lesions, but relapses occurred when these systemic corticosteroids were tapered.
一名24岁男性面部反复出现坏死性丘疹水疱。皮肤损害始于红斑，随后出现水疱、坏死和结痂，并留下凹陷性瘢痕。避光并不能阻止皮损的发展。组织学检查显示淋巴细胞增生性病变局限于皮肤。通过原位杂交在皮肤损害的淋巴细胞中检测到潜伏性EB病毒（EBV）感染。中至高剂量的糖皮质激素可抑制新皮肤损害的发展，但当这些全身性糖皮质激素逐渐减量时会复发。
