de Waal E J, de Jong W H, van der Stappen A J, Verlaan B, van Loveren H
Laboratory for Medicines and Medical Devices, National Institute of Public Health and The Environment, Bilthoven, The Netherlands.
Int J Immunopharmacol. 1999 Aug;21(8):523-9. doi: 10.1016/s0192-0561(99)00030-2.
Salmeterol is a long-acting beta2-adrenoreceptor agonist. The compound has previously been screened for immunotoxic potential in a repeated dose toxicity study in rats for 28 days. The total serum IgG levels were increased at dose levels of 2 and 10 mg/kg/day. Presently, salmeterol was studied in an immune function assay addressing the host resistance to Trichinella spiralis parasites. Rats were daily treated with salmeterol for 28 days at dose levels of 0, 2, 6 and 10 mg/kg/day. On day 29, the animals were infected with T. spiralis parasites. After six weeks, host resistance was examined. The numbers of T. spiralis muscle larvae in the tongue nor the inflammatory reactions around the encapsulated larvae were affected by salmeterol treatment. The yield of muscle larvae in the whole carcass was not changed either. The IgM, IgA and IgE antibody responses to T. spiralis were unaffected. Only at the highest dose level tested, the anti-T. spiralis IgG antibody response was decreased significantly. However, salmeterol's interference with the generation of anti-T. spiralis antibodies of the IgG subclass apparently did not adversely affect the resistance to infection.
沙美特罗是一种长效β2肾上腺素能受体激动剂。该化合物先前已在大鼠重复给药28天的毒性研究中进行了免疫毒性潜力筛选。在剂量水平为2和10mg/kg/天时，总血清IgG水平升高。目前，在一项针对宿主对旋毛虫寄生虫抵抗力的免疫功能试验中对沙美特罗进行了研究。大鼠每天以0、2、6和10mg/kg/天的剂量水平用沙美特罗治疗28天。在第29天，动物感染旋毛虫寄生虫。六周后，检查宿主抵抗力。沙美特罗治疗对舌部旋毛虫肌肉幼虫数量或包囊幼虫周围的炎症反应均无影响。整个胴体的肌肉幼虫产量也没有变化。对旋毛虫的IgM、IgA和IgE抗体反应未受影响。仅在测试的最高剂量水平下，抗旋毛虫IgG抗体反应显著降低。然而，沙美特罗对IgG亚类抗旋毛虫抗体产生的干扰显然并未对感染抵抗力产生不利影响。
