Int J Gynaecol Obstet. 1999 Jul;66(1):63-70.
The reduction in the incidence of Rh D alloimmunization is a prototype for the effectiveness of preventive medicine. Some controversies remain, however, such as the use of anti-D immune globulin in patients with either threatened abortion or antenatal hemorrhage. Similarly, it may not be cost-effective either to screen all Rh D-negative patients with an indirect Coombs test at 24-28 weeks of gestation or to screen all postpartum patients for excessive fetomaternal hemorrhage.
Rh D 同种免疫发生率的降低是预防医学有效性的一个典范。然而，仍存在一些争议，例如在有先兆流产或产前出血的患者中使用抗 D 免疫球蛋白。同样，在妊娠 24 - 28 周时对所有 Rh D 阴性患者进行间接抗人球蛋白试验筛查，或对所有产后患者进行胎儿 - 母体大量出血筛查，可能都不具有成本效益。
