Mazokhin V N, Kolmakov D N, Lucheyov N A, Gelvich E A, Troshin I I
Institute of Scientific Research Istok, Fryazino, Moscow region, Russia.
Int J Hyperthermia. 1999 Jul-Aug;15(4):309-29. doi: 10.1080/026567399285675.
The structure and main features of a HF EM installation based upon a new approach for creating electromagnetic fields destined for whole body (WBH) and deep local (DLH) hyperthermia are discussed. The HF EM field, at a frequency of 13.56 MHz, is created by a coplanar capacity type applicator positioned under a distilled water filled bolus that the patient is lying on. The EM energy being released directly in the deep tissues ensures effective whole body heating to required therapeutic temperatures of up to 43.5 degrees C, whereas the skin temperature can be maintained as low as 39-40.5 degrees C. For DLH, the installation is equipped with additional applicators and a generator operating at a frequency of 40.68 MHz. High efficiency of the WBH applicator makes it possible to carry out the WBH procedure without any air-conditioning cabin. Due to this, a free access to the patient's body during the WBH treatment is provided and a simultaneous WBH/DLH or WBH/LH procedure by means of additional applicators is possible. Controllable power output in the range of 100-800 W at a frequency of 13.56 MHz and 50-350 W at a frequency of 40.68 MHz allows accurate temperature control during WBH, DLH and WBH/DLH procedures. SAR patterns created by the WBH and DLH applicators in a liquid muscle phantom and measured by means of a non-perturbing E-dipole are investigated. The scattered EM field strength measured in the vicinity of the operating installation during the WBH, DLH and WBH/DLH procedures does not exceed security standards. Examples of temperature versus time graphs in the course of WBH, DLH and WBH/DLH procedures in clinics are presented. The installation is successfully used in leading oncological institutions of Russia and Belarus, though combined WBH/DLH procedures are evidently more complicated and demand thorough planning and temperature measurements to avoid overheating.
讨论了一种基于全新方法创建用于全身（WBH）和深部局部（DLH）热疗的电磁场的高频电磁设备的结构和主要特征。频率为13.56 MHz的高频电磁场由位于患者躺卧的充满蒸馏水的水垫下方的共面电容式 applicator 产生。直接在深部组织中释放的电磁能量可确保将全身有效加热至高达43.5摄氏度的所需治疗温度，而皮肤温度可维持在低至39 - 40.5摄氏度。对于DLH，该设备配备了额外的 applicator 和频率为40.68 MHz运行的发生器。WBH applicator 的高效率使得无需任何空调舱即可进行WBH程序。因此，在WBH治疗期间可自由接触患者身体，并且通过额外的 applicator 同时进行WBH/DLH或WBH/LH程序成为可能。在13.56 MHz频率下100 - 800 W范围内以及在40.68 MHz频率下50 - 350 W范围内的可控功率输出允许在WBH、DLH和WBH/DLH程序期间精确控制温度。研究了WBH和DLH applicator 在液体肌肉模型中产生并通过非扰动E偶极子测量的比吸收率（SAR）模式。在WBH、DLH和WBH/DLH程序期间在运行设备附近测量的散射电磁场强度不超过安全标准。给出了临床中WBH、DLH和WBH/DLH程序过程中的温度与时间关系图示例。该设备已在俄罗斯和白俄罗斯的领先肿瘤机构成功使用，不过联合的WBH/DLH程序显然更为复杂，需要进行全面规划和温度测量以避免过热。
