睡前单次服用曲唑酮对伴有抑郁状态的睡眠障碍的影响：不联用催眠药物的剂量探索研究
Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: dose-finding study with no concomitant use of hypnotic agent.
作者信息
Mashiko H, Niwa S, Kumashiro H, Kaneko Y, Suzuki S, Numata Y, Horikoshi R, Watanabe Y
机构信息
Department of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima-City, Japan.
出版信息
Psychiatry Clin Neurosci. 1999 Apr;53(2):193-4. doi: 10.1046/j.1440-1819.1999.00532.x.
This was the first dose-finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.
这是第一项旨在不联合使用催眠药的曲唑酮剂量探索研究，该药物以单剂量给药用于治疗合并抑郁状态的睡眠障碍。结果，50 - 100毫克/天剂量的曲唑酮改善了睡眠障碍，尤其是100毫克/天剂量时。证实了曲唑酮在睡前单剂量给药且不联合使用催眠药时，可改善合并抑郁状态的睡眠障碍。
Zotero 插件