Hisanaga A, Saitoh O, Fukuda H, Kurokawa K, Okabe A, Tachibana H, Hagino H, Mita T, Yamashita I, Tsutsumi M, Kurachi M, Itoh T
Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Psychiatry Clin Neurosci. 1999 Apr;53(2):303-5. doi: 10.1046/j.1440-1819.1999.00512.x.
The following describes a 76-year-old male with obstructive sleep apnea syndrome successfully treated with a Kampo-formula, San'o-shashin-to (Formula medicamentorum tres ad dispellendi cordis). Polysomnography, performed before and after administration of San'o-shashin-to, revealed that the apnea index decreased from 11.1 events/hour to 4.1 events/hour, and that the apnea plus hypopnea index decreased from 18.4 events/hour to 10.7 events/hour. The patient was normo-weight (body mass index: 20.4 kg/m2), and events of sleep apnea and hypopnea were mostly noted during a non-rapid eye movement sleep. It is possible that San'o-shashin-to has some alleviating effects on the upper airway resistance during sleep.
以下描述了一名76岁男性阻塞性睡眠呼吸暂停综合征患者，其通过汉方药三黄泻心汤（三物泻心汤）成功治愈。在服用三黄泻心汤前后进行的多导睡眠图检查显示，呼吸暂停指数从11.1次/小时降至4.1次/小时，呼吸暂停加低通气指数从18.4次/小时降至10.7次/小时。该患者体重正常（体重指数：20.4kg/m²），睡眠呼吸暂停和低通气事件大多发生在非快速眼动睡眠期间。三黄泻心汤可能对睡眠期间的上气道阻力有一定的缓解作用。
