Miura H, Kitagami T, Ohta T
Department of Psychiatry, Nagoya University School of Medicine, Japan.
Psychiatry Clin Neurosci. 1999 Jun;53(3):381-5. doi: 10.1046/j.1440-1819.1999.00561.x.
In the present study we applied the Zung self-rating depression scale (SDS) to 19 renal failure patients who were introduced to haemodialysis in the Nagoya Daini Red Cross Hospital, Nagoya, Japan. The patients were divided into two groups: the emergent introduction (EI) group, who underwent unanticipated and sudden introduction to haemodialysis, and the ordinary introduction (OI) group, who experienced a more systematic introduction to haemodialysis following recommendation by medical specialists. The patients' Zung SDS responses were collected twice, just before and 2 weeks after haemodialysis introduction. The total SDS score of the EI group was significantly higher than that of the OI group, both before and after haemodialysis introduction. The total SDS scores for the EI and OI groups were significantly reduced after haemodialysis introduction. The SDS scores for the EI group were significantly higher in the mood of depression and cognitive symptoms categories, both before and after haemodyalysis introduction. Before introduction, SDS scores of the EI group were significantly higher in the categories of motor and vegetative symptoms. The SDS scores for vegetative symptoms in the EI group significantly decreased after introduction to haemodialysis. These results suggest that haemodialytic excretion of uremic toxins helps to reduce SDS scores.
在本研究中,我们对日本名古屋第二红十字医院19名开始接受血液透析的肾衰竭患者应用了zung自评抑郁量表(SDS)。患者被分为两组:紧急透析组(EI组),即意外且突然开始接受血液透析的患者;常规透析组(OI组),即经医学专家建议后接受更系统血液透析的患者。在血液透析开始前及开始后2周,分别收集患者的zung SDS反应。血液透析开始前及开始后,EI组的SDS总分均显著高于OI组。血液透析开始后,EI组和OI组的SDS总分均显著降低。血液透析开始前及开始后,EI组在抑郁情绪和认知症状类别中的SDS评分均显著更高。开始前,EI组在运动和植物神经症状类别中的SDS评分显著更高。EI组在开始血液透析后,植物神经症状的SDS评分显著降低。这些结果表明,尿毒症毒素的血液透析清除有助于降低SDS评分。