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[胸膜孤立性纤维瘤]

[Solitary fibrous tumors of the pleura].

作者信息

Meyer M, Krause U

机构信息

Klinik für Herz- und Thoraxchirurgie, Martin-Luther-Universität, Halle-Wittenberg.

出版信息

Chirurg. 1999 Aug;70(8):949-52. doi: 10.1007/s001040050750.

Abstract

Solitary fibrous tumors of the pleura (SFTP) are very rare neoplasms. The majority of these tumors are benign, but about 10-20 % fulfill the criteria of malignancy. The clinical presentation varies according to the size and intrathoracic localization. In early stages, often asymptomatic, the tumors may grow to an enormous size and then cause symptoms such as cough, chest pain and dyspnea, but also paraneoplastic syndromes such as hypoglycemia or digital clubbing. Between 1981 and June 1998 we treated in our institution 16 SFTP in 14 patients (4 M, 10 F, average age at first operation 58 years). Eight patients showed symptoms, whereas in the other cases the tumors were found on routine chest X-rays. The usually pedunculated SFTP were completely resected without complications. Two patients developed malignant recurrences, which infiltrated the right upper lung lobe and the diaphragm respectively. In these cases the tumor was resected together with the adjacent structures. Since late recurrences are more often malignant than primary SFTPs long-term follow-up is mandatory even in benign lesions.

摘要

胸膜孤立性纤维瘤(SFTP)是非常罕见的肿瘤。这些肿瘤大多数是良性的,但约10%-20%符合恶性标准。临床表现因肿瘤大小和胸腔内位置而异。在早期,肿瘤通常无症状,可生长到巨大尺寸,然后引起咳嗽、胸痛和呼吸困难等症状,还可导致低血糖或杵状指等副肿瘤综合征。1981年至1998年6月,我们机构共治疗了14例患者的16个胸膜孤立性纤维瘤(4例男性,10例女性,首次手术时的平均年龄为58岁)。8例患者有症状,而其他病例的肿瘤是在常规胸部X线检查时发现的。通常带蒂的胸膜孤立性纤维瘤被完整切除,无并发症。2例患者出现恶性复发,分别侵犯右上肺叶和膈肌。在这些病例中,肿瘤与相邻结构一并切除。由于晚期复发比原发性胸膜孤立性纤维瘤更常为恶性,即使是良性病变也必须进行长期随访。

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