Mangasser-Stephan K, Gressner A M
Institut für Klinische Chemie und Pathobiochemie, Zentrallaboratorium, RWTH-Universitätsklinikum, Pauwelsstrasse 30, D-52057 Aachen, Germany.
Cell Tissue Res. 1999 Sep;297(3):363-70. doi: 10.1007/s004410051364.
Latent transforming growth factor-beta (TGFbeta) binding protein (LTBP), a component of the high-molecular-weight latent TGFbeta complex, is found in various cell and tissue types. Originally described as a TGFbeta-masking protein, recent detections of four isoforms and numerous splice variants provide new aspects of its putative functional role. Regulation and sequestration of TGFbeta activity and structural remodeling of the extracellular matrix (ECM) seem to be the main tasks, but other possible functions might exist. The mechanism by which LTBP interacts with cell surface molecules or cellular receptors and ECM components remains unclear. Cellular, molecular and functional aspects will be discussed.
潜伏转化生长因子-β（TGFβ）结合蛋白（LTBP）是高分子量潜伏TGFβ复合物的一个组成部分，存在于多种细胞和组织类型中。最初被描述为一种TGFβ掩盖蛋白，最近发现的四种异构体和众多剪接变体为其假定的功能作用提供了新的视角。TGFβ活性的调节和隔离以及细胞外基质（ECM）的结构重塑似乎是其主要任务，但可能还存在其他功能。LTBP与细胞表面分子或细胞受体以及ECM成分相互作用的机制仍不清楚。本文将讨论其细胞、分子和功能方面的内容。
