Guy S R, Magliocca J F, Fruchtman S, McDonough P, Emre S, Kim-Schluger L, Sheiner P A, Fishbein T M, Schwartz M E, Miller C M
The Recanati/Miller Transplantation Institute, Mount Sinai Medical Center, Box 1104, One Gustave L. Levy Place, New York, New York 10029-6574, USA.
Transpl Int. 1999;12(4):278-80. doi: 10.1007/s001470050223.
The liver is the primary site of synthesis for the majority of coagulation factors. There are published accounts of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia and factor XI deficiency. In this article, we report what we believe to be the first observation, of transmission of factor VII deficiency, a rare, autosomal recessive coagulation disorder, from an affected liver donor to a naive liver recipient. At 300 days after transplantation, the recipient remains with an isolated prolongation of the prothrombin time and a below-normal level of factor VII, and has had no bleeding complications.
肝脏是大多数凝血因子的主要合成部位。已有关于肝移植供体向受体传播蛋白C缺乏伴异常纤维蛋白原血症和因子XI缺乏的报道。在本文中，我们报告了我们认为是首例因子VII缺乏（一种罕见的常染色体隐性凝血障碍）从受影响的肝供体传播给未感染的肝受体的观察结果。移植后300天，受体的凝血酶原时间仍单独延长，因子VII水平低于正常，且未出现出血并发症。
