Nishida M, Kawakatsu H, Ishiwari K, Tamai M, Sawada T, Nishimura M, Yoshimura M
Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Am J Nephrol. 1999;19(4):509-12. doi: 10.1159/000013508.
The serum levels of hepatocyte growth factor (HGF) were determined in patients with various renal diseases. In patients with acute-phase acute renal failure (ARF) and chronic tubulointerstitial nephritis (chronic TIN), the serum HGF levels were 0.55 +/- 0.24 and 0.44 +/- 0.37 ng/ml (mean +/- SD), respectively, and were significantly higher than that in the control group (0.12 +/- 0.12 ng/ml). The serum HGF level tended to be high also in patients with active-phase steroid-sensitive nephrotic syndrome (SSNS). The serum levels of HGF were not elevated in patients with IgA nephropathy (IgAN), Henoch-Schönlein purpura nephritis (HSPN), membranoproliferative glomerulonephritis (MPGN), poststreptococcal acute glomerulonephritis (PSAGN), unilateral renal atrophy, unilateral nephrectomy, or proximal tubular dysfunction. These observations suggest that glomerular disorders cause no apparent elevation of the serum HGF level, and that elevation of the serum HGF level may be associated with tubulointerstitial damage in renal diseases.
测定了各种肾脏疾病患者的肝细胞生长因子（HGF）血清水平。在急性期急性肾衰竭（ARF）和慢性肾小管间质性肾炎（慢性TIN）患者中，血清HGF水平分别为0.55±0.24和0.44±0.37 ng/ml（均值±标准差），显著高于对照组（0.12±0.12 ng/ml）。在活动期激素敏感型肾病综合征（SSNS）患者中，血清HGF水平也往往较高。IgA肾病（IgAN）、过敏性紫癜肾炎（HSPN）、膜增生性肾小球肾炎（MPGN）、链球菌感染后急性肾小球肾炎（PSAGN）、单侧肾萎缩、单侧肾切除或近端肾小管功能障碍患者的血清HGF水平未升高。这些观察结果表明，肾小球疾病不会导致血清HGF水平明显升高，血清HGF水平升高可能与肾脏疾病中的肾小管间质损伤有关。
