甲状腺自身免疫患者中乳糜泻的患病率。
Prevalence of coeliac disease in patients with thyroid autoimmunity.
作者信息
Valentino R, Savastano S, Tommaselli A P, Dorato M, Scarpitta M T, Gigante M, Micillo M, Paparo F, Petrone E, Lombardi G, Troncone R
机构信息
CNR, Experimental Endocrinology and Oncology Center (CEOS), Department of Cellular and Molecular Biology and Pathology, University Federico II, Naples, Italy.
出版信息
Horm Res. 1999;51(3):124-7. doi: 10.1159/000023344.
The occurrence of autoimmune thyroid disorders among patients with coeliac disease (CD) is well documented, but the exact prevalence of CD among patients with autoimmune thyroid diseases (ATD) is as yet unclear. We screened 150 newly diagnosed patients with ATD by serum endomysial antibody detection (EmA). In 5 subjects (3.3%) EmA positivity was found; all underwent jejunal biopsy. On gluten-free diet an excellent clinical and histological response was recorded with an improvement of hypothyroidism and reduction of the thyroxine dosage. Our data suggest a significant high prevalence (3.3%) of CD in patients with ATD, in particular with Hashimoto's thyroiditis.
乳糜泻（CD）患者中自身免疫性甲状腺疾病的发生已有充分记录，但自身免疫性甲状腺疾病（ATD）患者中CD的确切患病率尚不清楚。我们通过血清抗肌内膜抗体检测（EmA）对150例新诊断的ATD患者进行了筛查。在5名受试者（3.3%）中发现EmA呈阳性；所有患者均接受了空肠活检。采用无麸质饮食后，记录到了良好的临床和组织学反应，甲状腺功能减退得到改善，甲状腺素剂量减少。我们的数据表明，ATD患者，尤其是桥本甲状腺炎患者中CD的患病率显著较高（3.3%）。
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