Ashok Tejaswini, Patni Nassar, Fatima Mahejabeen, Lamis Aselah, Siddiqui Shiza W
Internal Medicine, Jagadguru Sri Shivarathreeshwara (J.S.S) Medical College, Mysore, IND.
Internal Medicine, Deccan College of Medical Sciences, Hyderabad, IND.
Cureus. 2022 Jun 23;14(6):e26243. doi: 10.7759/cureus.26243. eCollection 2022 Jun.
Celiac disease (CD) is a small intestinal inflammatory disease commonly seen in the Western population. It has been observed that patients with monoglandular and polyglandular autoimmunity have a higher prevalence of celiac disease. Hashimoto's thyroiditis (HT) and Graves' disease (GD), which mainly constitute the autoimmune thyroid diseases (AITD), characterized by lymphocytic infiltration of the thyroid parenchyma, are noted to be frequently associated with celiac disease. The fundamental mechanism of this frequent coexistence is thought to be a shared genetic background. Due to the subclinical nature of the celiac disease, the diagnosis is often missed or made coincidentally during screening. The rising prevalence of the celiac disease among AITD patients has urged researchers to investigate the link between the two. We reviewed the most recent and relevant literature on the intriguing relationship between celiac disease and thyroid autoimmunity. The objectives of this article were to study the shared genetic background, the incidence of CD in AITD, the effect of a gluten-free diet on AITD, and the need for routine screening of CD in AITD patients.
乳糜泻（CD）是一种常见于西方人群的小肠炎症性疾病。据观察，患有单腺体和多腺体自身免疫性疾病的患者患乳糜泻的患病率更高。桥本甲状腺炎（HT）和格雷夫斯病（GD）主要构成自身免疫性甲状腺疾病（AITD），其特征为甲状腺实质的淋巴细胞浸润，被认为常与乳糜泻相关。这种频繁共存的基本机制被认为是共享的遗传背景。由于乳糜泻的亚临床性质，诊断常常被遗漏或在筛查过程中偶然做出。AITD患者中乳糜泻患病率的上升促使研究人员去探究两者之间的联系。我们回顾了关于乳糜泻与甲状腺自身免疫性之间有趣关系的最新及相关文献。本文的目的是研究共享的遗传背景、AITD中CD的发病率、无麸质饮食对AITD的影响以及对AITD患者进行CD常规筛查的必要性。
