Koury R, Stone C K, Stapczynski J S, Blake J
Department of Emergency Medicine, University of Kentucky Medical Center, Lexington 40536-0236, USA.
Eur J Emerg Med. 1999 Jun;6(2):149-52. doi: 10.1097/00063110-199906000-00012.
A 24-year-old male presented to the emergency department with hyperadrenergic manifestations of fenfluramine-phentermine overdose: tachycardia, mydriasis, fever, diaphoresis, hyperventilation, and combativeness. Sedatives, neuromuscular paralytics, adrenergic antagonists, and mechanical ventilation were required to care for the patient. In addition, the patient had self-inflicted 15% TBSA second-degree burns and developed adult respiratory distress syndrome which required continued intubation and mechanical ventilation for 12 days. The patient had split thickness skin grafts for his leg burns on day 11. He was discharged after a 26-day hospital stay. We are unaware of any previously reported cases of fenfluramine-phentermine overdose with such profound degree of sympathetic storm.
一名24岁男性因服用芬氟拉明-苯丙胺过量出现高肾上腺素能表现而就诊于急诊科，症状包括心动过速、瞳孔散大、发热、多汗、通气过度和攻击性。护理该患者需要使用镇静剂、神经肌肉阻滞剂、肾上腺素能拮抗剂及机械通气。此外，患者有15%体表面积的自伤二度烧伤，并发展为成人呼吸窘迫综合征，需要持续插管及机械通气12天。患者在第11天接受了腿部烧伤的分层皮片移植。住院26天后出院。我们未发现之前有任何关于芬氟拉明-苯丙胺过量且伴有如此严重交感神经风暴程度的病例报道。
