Teranishi Y, Ozono R, Yoshimizu A, Ueda A, Kurisu S, Tsuru H
Department of Physiology, Hiroshima University School of Medicine, Japan.
Gen Pharmacol. 1999 Aug;33(2):127-36. doi: 10.1016/s0306-3623(99)00003-8.
One of two Ca antagonists, benidipine (3-30 microg/kg) or nifedipine (30-600 g/kg), was administered in a bolus injection through the jugular vein, and the changes in mean arterial pressure (MAP), renal flow (RF), and hindquarter flow (HQF) in conscious spontaneously hypertensive rats (SHRs) and normotensive control rats (NCRs). Renal vascular resistance (RR) and hindquarter resistance (HQR) were calculated as MAP divided by RF and HQF, respectively. When a high dose was administered to decrease the blood pressure by about 20%, the RR was significantly lower with benidipine than with nifedipine. The decrease in HQR was not significantly different between benidipine and nifedipine. When a low dose was administered to decrease the blood pressure by about 7%, the decrease in RR was not significantly different between benidipine and nifedipine, but the HQR was significantly lower with benidipine than with nifedipine. In the NCRs, no pharmacological properties were significantly different between these two Ca antagonists.
两种钙拮抗剂之一，贝尼地平（3 - 30微克/千克）或硝苯地平（30 - 600微克/千克），经颈静脉大剂量注射给药，观察清醒自发性高血压大鼠（SHR）和正常血压对照大鼠（NCR）的平均动脉压（MAP）、肾血流量（RF）和后肢血流量（HQF）的变化。肾血管阻力（RR）和后肢阻力（HQR）分别计算为MAP除以RF和HQF。当给予高剂量使血压降低约20%时，贝尼地平组的RR显著低于硝苯地平组。贝尼地平和硝苯地平组HQR的降低无显著差异。当给予低剂量使血压降低约7%时，贝尼地平和硝苯地平组RR的降低无显著差异，但贝尼地平组的HQR显著低于硝苯地平组。在NCR中，这两种钙拮抗剂的药理学特性无显著差异。
