Kroon F P, van Dissel J T, Ravensbergen E, Nibbering P H, van Furth R
Leiden University Medical Center, Department of Infectious Diseases, The Netherlands.
Vaccine. 1999 Aug 6;17(23-24):2941-5. doi: 10.1016/s0264-410x(99)00167-x.
Infections with Salmonella species, including Salmonella typhi, are more frequently observed in HIV-infected individuals than in healthy individuals. HIV-infected individuals were vaccinated with polysaccharide vaccine against Salmonella typhi (Typhim-Vi) which is assumed to be a T-cell-independent antigen. We found that the antibody response in patients with < 200 x 10(6)/l CD4+ T lymphocytes was significantly lower compared with patients with > or = 200 x 10(6)/l CD4+ T lymphocytes and healthy controls. The antibody response after vaccination with the polysaccharide salmonella Vi-antigen was correlated with the number of CD4+ T lymphocytes and therefore Typhim-Vi can be considered to be a T-cell-independent type 2 antigen. The results of this study indicate that after vaccination the proportion of HIV-infected individuals with protective antibody concentrations against Salmonella typhi will be lower than in healthy controls.
包括伤寒沙门氏菌在内的沙门氏菌属感染在艾滋病毒感染者中比在健康个体中更常见。给艾滋病毒感染者接种了针对伤寒沙门氏菌的多糖疫苗（Typhim-Vi），该疫苗被认为是一种非T细胞依赖性抗原。我们发现，CD4+T淋巴细胞<200×10⁶/l的患者的抗体反应与CD4+T淋巴细胞≥200×10⁶/l的患者及健康对照相比显著更低。接种多糖伤寒Vi抗原后的抗体反应与CD4+T淋巴细胞数量相关，因此Typhim-Vi可被认为是一种非T细胞依赖性2型抗原。本研究结果表明，接种疫苗后，艾滋病毒感染者中具有针对伤寒沙门氏菌的保护性抗体浓度的个体比例将低于健康对照。
