Meczekalski B, Warenik-Szymankiewicz A, Halerz-Nowakowska B
Katedry i Kliniki Endokrynologii Ginekologicznej Akademii Medycznej w Poznaniu.
Ginekol Pol. 1999 May;70(5):333-7.
Pathophysiology of weight loss related amenorrhea is not fully understood. Disturbances in GnRH pulsatility play a key role in this state. There is a group of neuropeptides (CRH, TRH) which inhibit GnRH secretion and also neuropeptides (galanin, Neuropeptide Y) which can stimulate GnRH release. Therefore the aim of study was to evaluate the serum galanin, FSH, LH, estradiol levels in young women with secondary amenorrhea after weight loss and in normal women Serum galanin, FSH, LH, estradiol levels were measured with the use of radioimmunoassay methods. There was no significant difference in serum galanin levels between amenorrheic women and control. FSH, LH and estradiol levels in amenorrheic women were significantly lower than in control. We conclude that serum galanin levels appear to be comparable in amenorrheic and normal women.
体重减轻相关闭经的病理生理学尚未完全明了。促性腺激素释放激素（GnRH）脉冲分泌紊乱在这种状态中起关键作用。有一组神经肽（促肾上腺皮质激素释放激素、促甲状腺激素释放激素）抑制GnRH分泌，也有神经肽（甘丙肽、神经肽Y）可刺激GnRH释放。因此，本研究的目的是评估体重减轻后继发性闭经年轻女性和正常女性的血清甘丙肽、卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇水平。采用放射免疫分析法测定血清甘丙肽、FSH、LH、雌二醇水平。闭经女性与对照组血清甘丙肽水平无显著差异。闭经女性的FSH、LH和雌二醇水平显著低于对照组。我们得出结论，闭经女性和正常女性的血清甘丙肽水平似乎相当。
